Reprogramming Enzymes for Chemistry Beyond Nature

We combine directed evolution, visible light, and electricity to create mild, selective biocatalysis for chiral molecule synthesis.

Research

We use enzymes, light, and electricity to develop mild and selective ways to make chiral molecules.

Our work connects biocatalysis, synthetic chemistry, protein engineering, and synthetic biology.

Enzymes + Light + Electricity Chiral molecules

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Biocatalysis Photoenzymatic catalysis Electroenzymatic catalysis Synthetic biology

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X-MOL

Latest group news is maintained on the Huang Group X-MOL page.

Selected Publications

Representative work

All publications

A light-driven enzymatic enantioselective radical acylation.

Xu, Y.; Chen, H.; Yu, L.; Peng, X.; Zhang, J.; Xing, Z.; Bao, Y.; Liu, A.; Zhao, Y.; Tian, C.*; Liang, Y.*; Huang, X.* Nature 2024, 625, 74-78.

Graphical abstract for light-driven enzymatic radical acylation

Synergistic photobiocatalysis for enantioselective triple radical sorting.

Xing, Z.; Liu, F.; Feng, J.; Yu, L.; Wu, Z.; Zhao, B.; Chen, B.; Ping, H.; Xu, Y.; Liu, A.; Zhao, Y.; Wang, C.; Wang, B.*; Huang, X.* Nature 2025, 637, 1118-1123.

Graphical abstract for synergistic triple radical sorting

Electricity-driven enzymatic dynamic kinetic oxidation.

Zhao, B.; Xu, Y.; Zhu, Q.; Liu, A.; Peng, X.; Zhang, T.; Yu, L.; Zhang, Y.; Huang, X.* Nature 2025, 643, 699-704.